Proposed mechanism of anti-CD44-mediated FcγR inhibition. A proposed mechanism for anti-CD44–mediated inhibition of macrophage FcγRs. Anti-CD44’s antigen-binding region engages with CD44, and the Fc region of anti-CD44 binds to adjacent FcγRs, mediating blockade/inhibition of the FcγRs. Objects are not to scale. MΦ, macrophage.