Inter-individual clonotype sharing. (A) Subset 2 heavy chains. All VH CDR3 detected in the subset 2 cohort are depicted by a bubble or dot. The size of the bubbles reflects the relative frequency of each clonotype based on the total number of reads encoding that particular clonotype across all samples. The VH CDR3 of some of the most expanded clonotypes within the entire cohort are stated in the corresponding bubble, and the number of patients sharing that particular clonotype is indicated in the brackets. Most of the expanded clonotypes are shared among different patients (the full list of the entire heavy chain subset 2 clonotypes is given in supplemental Table 8A; for the shared clonotypes, see supplemental Table 9) (B) IGLV3-21 light chains. The entire sequence data set of IGLV3-21 gene rearrangements with 12-aa-long VL CDR3 cohort is depicted. The size of the bubbles reflects the relative frequency of each clonotype based on the total number of reads encoding that particular clonotype across all samples. Some of the expanded clonotypes of the cohort are labeled, and the number of patients sharing that particular clonotype is indicated in the brackets. Most of the expanded clonotypes are shared among different patients (the full list of the entire LC IGLV3-21 with 12-aa-long clonotypes is given in supplemental Table 11A; for the shared clonotypes, see supplemental Table 12).