PT25-2 binding does not induce hybrid domain swing-out. (A) Overlay of the αIIbβ3 headpiece in complex with PT25-2 (red) and the headpiece of unliganded αIIbβ3 (PDB: 3FCS) (blue). (B) Overlay of the αIIbβ3 headpiece in complex with PT25-2 (red) and the headpiece of αIIbβ3 in complex with the fibrinogen γ-chain C-terminal dodecapeptide (PDB: 2VDO) (green). (C) Overlay of all 3 αIIbβ3 headpiece structures. ADMIDAS, adjacent to MIDAS; βI, β-inserted domain.