SMOC1 expression in platelets from healthy donors and subjects with type 2 diabetes. Washed platelets were isolated from nondiabetic subjects (healthy; H) and individuals with type 2 diabetes (D). (A) PAR1 and PAR4 expression; n = 6 per group, **P < .01, Student t test. (B) SMOC1 and β1-integrin (β1) levels; n = 8 per group. ***P < .001, Student t test. (C) Thrombin-induced platelet aggregation in the presence of solvent (Sol), an antibody against SMOC1 (abS1), or an anti–β-actin antibody (abβ); n = 6 subjects per group. ***P < .001, 2-way ANOVA and Bonferroni test.