Characterization of hypomethylated and hypermethylated regions in mouse models with Dnmt3a and/or Tet2 mutations compared with HSPCs. Heatmap of beta scores for each hypomethylated (A) or hypermethylated (B) genomic region (row) clustered by using k-means; each column represents one sample, and genotypes are shown on top. Centroid of beta score for each cluster is shown on the left. The pie charts describe the overlap between hypomethylated (C) and hypermethylated (D) genomic regions and known genetic regions (mm9). Percentage of genomic regions in hypomethylated (E) or hypermethylated (F) clusters that overlap with SUZ12, P300, and MYB binding sites (http://useast.ensembl.org/info/genome/funcgen/index.html). UTR, untranslated region.