Summary scheme graphic showing a link between PKM2-mediated cellular signaling, platelet function, and thrombosis. In the presence of excess glucose, dimeric PKM2 helps in glucose uptake, and lactate production enhances platelet activation and aggregation via PI3K-mediated Akt/GSK3β signaling to submaximal stimulus-response to GPVI agonists (collagen and convulxin) and GPCR agonists (ADP and thrombin). Glut1, glucose transporter 1; Glut3, glucose transporter 3; PEP, phosphoenolpyruvate; TCA, tricarboxylic acid.