IKZF1 mutational and deletion patterns according to patient occurrence. (A) Gene map describing IKZF1 intragenic mutational patterns according to patient occurrence. (B) Gene map describing IKZF1 deletion patterns according to patient occurrence. (C) Genetic profiles of IKZF1^Alt T-ALL in the FRALLE and GRAALL 03-05 protocols. Comparison of mutational profiles according to pathways between IKZF1^Alt T-ALLs (n = 26) and IKZF1^GL T-ALLs (n = 450), with a focus on alterations found in at least 5% of the whole cohort. Percent frequencies in each group are indicated. Genes are grouped according to functional categories. OS (D) and cumulative incidence of relapse (E) in FRALLE and GRAALL treated patients. *P < .05. IL7R, interleukin-7 receptor; PI3K-Akt, phosphatidylinositol 3-kinase/protein kinase B.