Genetic abnormalities in BPDCN. (A) Mutational profile and key deletions or rearrangements in BPDCN. (B) Circle plot in BPDCN. Blue: biallelic mutation; lavender: monoallelic mutation; lime green: chromosomic loss; green: biallelic invalidation by both chromosome loss and mutation of the other allele; light red: MYC or MYC rearrangement; gray: not done. In the karyogram, deletions are depicted by green bars on the left of the chromosome, gains by red bars on the right of the chromosome, and mutations by blue bars. (C) Expression levels of MYC in BPDCN and pDCs. (D) Expression levels of ETV6 in blue and TCL1A in red on microarrays. High expression of TCL1A and low expression of ETV6 are circled in full line.