Significantly improved platelet and megakaryocyte (MK) counts were observed in patients receiving decitabine treatment. (A) Platelet counts increased significantly in arms A and B during third week after decitabine administration. (B) Total MKs (per cm²), platelet-shedding MKs (per cm²), and MK polyploidy (%) in patients in arms A and B increased remarkably after treatment compared with those in arm C. (C) Representative microscopic images (Wright-Giemsa staining) of bone marrow biopsy in case 29 in arm A at week 0 (left) and week 4 (right) after treatment. Arrows indicate MKs. *P < .05. ns, not significant.