Gene expression signature is predictive of relapse in patients with CN-AML. (A) Receiver operating characteristic (ROC) curve shows the sensitivity and specificity of 10-gene expression signature for predicting relapse in 268 adult CN-AML patients younger than 60 years. (B) Predicted relapse probability for the 268 patients determined using the 10-gene signature. Each bar represents a patient, colored according to actual relapse status. (C) Predicted relapse probability for a validation set of 32 adult patients with CN-AML younger than 60 years included in the TCGA database,³¹  determined using the 10-gene signature. (D) ROC curve showing the sensitivity and specificity of the 10-gene expression signature for predicting relapse in the 32 TCGA patients with CN-AML. Maintain CR denotes CR maintained for ≥3 years.