Prediction corrected visual predictive check of the final integrated VWF/FVIII population PK model. The median and 2.5th and 97.5th percentile of the observed levels (black dots) at each bin are presented as the red line and the blue lines, respectively. The red and blue shaded boxes represent the median and 2.5th and 97.5th percentile of the 1000 simulated prediction corrected observations at each bin, respectively. (A) FVIII. (B) VWF:Act.