Neutrophils in CLL show impaired migration after bacterial infection of the urinary bladder. (A) GSEA of the proteome of blood neutrophils indicated migratory pathways to be particularly enriched with reduced expression of proteins involved in the migration of neutrophils. Detailed expression values are shown in supplemental Tables 11-15. (B) The heatmap indicates the expression intensities of proteins of the pathways extracellular matrix (ECM), focal adhesion, cell-cell adhesion, leukocyte cell-cell adhesion, and granulocyte migration in blood neutrophils in CLL-bearing mice. (C) Mice were infected with UPEC^GFP and the number of neutrophils per UPEC area [#/mm²] in relation to the bacterial burden were calculated. **P < .01. Data are mean ± SEM. (A-B) Non-CLL, n = 6; CLL, n = 12. (C) Non-CLL, n = 6; CLL, n = 6. C, cell-cell adhesion; E, ECM pathway; F, focal adhesion pathway; G, granulocyte migration pathway; L, leukocyte cell-cell adhesion pathway.