Increased IFN signaling and decreased protein expression critical for secretory granule and migration in blood neutrophils from CLL-bearing mice. (A) STRING analysis of the significant proteins (P < .01) of blood neutrophils from CLL-bearing mice. K-means clustering indicated enriched protein-protein interactions in the protein network. See supplemental Table 4 for a more detailed table. (B) Dot plot illustrating fold changes (log₂ of CLL vs non-CLL) of individual proteins of clusters indicated in panel A. (C-D) GSEA of the proteome of blood neutrophils in CLL vs non-CLL conditions. NESs were displayed in different sizes to reveal the FDR-adjusted P value and in different colors to indicate the protein ratio within the indicated pathway. See supplemental Tables 5 and 6 for more detailed tables. Non-CLL, n = 6; CLL, n = 12.