Figure 3.
IRX4204 modulates the transcription profile of gut-localized donor T cells. BALB/c recipients were lethally irradiated and infused with 107 B6 NTCD CD45.2 BM cells and 1.5 × 106 B6 CD45.1+ CD4+ T cells. Recipients were treated IP with either vehicle or IRX4204 daily. On day 18 after transplantation, LP donor (CD45.1+) T cells were isolated from the SI of treated recipients. RNA was isolated from these LP donor T cells for NanoString gene expression analysis (n = 4/group). PCA plots (A) and heat maps (B) are shown.

IRX4204 modulates the transcription profile of gut-localized donor T cells. BALB/c recipients were lethally irradiated and infused with 107 B6 NTCD CD45.2 BM cells and 1.5 × 106 B6 CD45.1+ CD4+ T cells. Recipients were treated IP with either vehicle or IRX4204 daily. On day 18 after transplantation, LP donor (CD45.1+) T cells were isolated from the SI of treated recipients. RNA was isolated from these LP donor T cells for NanoString gene expression analysis (n = 4/group). PCA plots (A) and heat maps (B) are shown.

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