Responses and outcome. (A) Response according to IWCLL criteria for the first 51 patients. “PR spleen only, no BM” indicate that a spleen diameter >13 cm was the only criteria for not achieving CR; 2 patients without BM data available are also included here. PR nodal <2.5 cm indicates that no lymph nodes were >2.5 cm in largest diameter; PR nodal +2.5 cm indicates that lymph nodes >2.5 cm in diameter were present. For the 6 patients stopping treatment, no response data were available; this includes the 2 fatalities. The 3 patients with unavailable response assessment represent 2 patients with clinical CR and 1 patient with clinical CR incomplete recovery due to thrombocytopenia. (B) Progression-free survival. The 2 fatal events are depicted; no progressions were reported. (C) Sankey plot for minimal residual response (MRD) of the first 51 eligible patients completing cycle 15. Kinetics is shown on PB and BM aspirates. uMRD indicates undetectable MRD <10−4 by flow cytometry; low MRD+ indicates MRD levels between 10−2 and 10−4; high MRD+ indicates MRD levels ≥10−2. To the right, MRD response in BM is shown for comparison with MRD response in PB at cycle 15; end of cycle 9 and end of cycle 12 samples are PB.