Motif landscape at differentially expressed genes. (A) Plot describes the top 45 motifs enriched at the 310 upregulated gene promoters. The bottom bar plot illustrates the relative enrichment of each motif (–log10 q value), and the number on top of each bar is the percentage of promoters enriched with the motif. The top line plot illustrates the expression of each of the 45 motifs in the HV samples (control) (gold) and the ET population (red). Green dots indicate genes that are significantly upregulated vs HV, and pink dots indicate genes that are significantly downregulated vs HV (control). The highlighted color segments correspond to the expression quantiles (green = highest, yellow = medium, orange = low). (B) Boxplots illustrating the expression levels of genes in the SET-2 cell line. The gold box is the distribution of all SET-2 genes; the pink box is the SET-2 expression levels of the 310 upregulated genes in the ET cohort; and the purple box is the SET-2 expression levels of upregulated genes with high H3k27ac deposition at their promoters. *The Student t test P value when comparing each box vs the expression of all genes (gold box).