Refining the CKs. (A) TGL, as measured by sWGS, for the 236 intensively treated patients (including 8 APLs) displayed with successively decreasing genomic loss size. TP53 mutational status, as well as CK and MK, as determined by CCA are shown below. (B) The status of 6 factors related to genomic complexity are presented as a heat map for the 236 patients with survival data. Patients (columns) are grouped according to the status of the 3 factors in green: CK and hyperdiploid karyotype (HDK) according to CCA and TGL >200 Mbp by sWGS. TGL is also shown as a continuous value in shades of red; darker shades correspond to higher TGL. TP53 mutation and MK according to CCA are shown at the bottom of the panel (positive cases in blue and negative cases in gray). The top row shows RFS, where relapses or deaths are shown in black/gray (the darker shade represents shorter time to relapse). Patients censored before reaching an event are shown in yellow (the longer the follow-up, the darker the shade). Patients are sorted by survival in each cluster, and P values were calculated using log-rank tests to compare 2 clusters. The width of columns in the first cluster was reduced for better readability.