Comparison between NGK and CCA over ELN criteria. (A) Agreement between sWGS and CCA on ELN CNA–based criteria at the patient level. The gray boxes represent patients for whom both techniques agreed to call the corresponding aberration. The proportion of patients in the entire cohort with these aberrations are shown inside the gray box. Colored boxes represent other patients for whom such an aberration was called by only 1 of the 2 competing techniques. Validation status of the discrepancies by FISH or LD-RTPCR is further indicated by a darker shade (confirmed) or by stripes (refuted). The scale on the left represents the absolute number of patients in each box. (B) Agreement between WTS and CCA on ELN translocations and PML-RARA, as presented in panel A. (C-D) OS and RFS of 228 non-APL patients treated with curative intent, assessing the ELN classification as performed by NGK (WTS + sWGS) techniques. ELN-defining gene mutations were assessed by DNA panel sequencing. (E-F) Survival of ELN subgroups, as defined by NGK techniques in which complex karyotype (CK) and monosomal karyotype (MK) are replaced by a  total genomic loss (TGL) threshold of 200 Mb. (G-H) Survival in ELN subgroups, as defined by NGK techniques.