Matching CNAs between sWGS and CCA. (A) Proportion of the 281 patients with AML presenting a copy gain (blue) or loss (red) are presented along the 22 autosomes. Chromosome banding is displayed between the tracks of each chromosome, with centromeres in dark red. (B) The 672 aberrations found by CCA, sWGS, or both in the entire cohort were classified according to criteria fully described in the supplemental Methods. Each column represents a level of subclassification, from the broader terms on the left to the more precise classes on the right. Box heights are proportional to the number of aberrations present in the corresponding class (displayed between parentheses at the end of each class name). Each aberration is present in only 1 class. (C) FISH validation of ELN CNAs differing between sWGS and CCA. In each case, the genotype confirmed by FISH is highlighted in green, and cases in gray correspond to inconclusive FISH experiments. All cases are detailed in supplemental Table 8. NI, not interpretable; NOS, not otherwise specified. *Uncertainty reported in CCA (eg, incomplete formula). **Subclonal event (<10%) in a sample with few cells interpretable by FISH. der, derivative chromosome; mar, marker chromosome.