BCR-PI3K-TLR is a major determinant of sensitivity/resistance to MALT1 inhibitors. (A) Graph representing significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways among genes whose knockdown decreased (A) and increased (B) sensitivity to MI-2 using STRING. (C) Graph picturing modulators of response to MALT1i significantly enriched in MI-2 shRNA combinatorial screen. Depleted (blue) or enriched (red) shRNAs in MI-2 vs. DMSO-treated cells and their relative position in the BCR/PI3K/TLR pathway network.