Schematics of genes annotated with oncogenic missense mutations found in CFCL. Mutations marked with red arrowheads (left column) denote validated gain-of-function missense mutations in putative oncogenes. Mutations marked with black arrowheads (right column) denote loss-of-function missense mutations in putative tumor-suppressor genes. Mutations marked with light blue arrowheads (right column) denote missense mutations that have not been functionally validated. Gray arrowheads denote known mutation hotspots.