Figure 1.
AK2 isoform exhibit robust expression in T-ALL. (A-B) Transcriptional expression of AK2 (A) and AK1 (B) in thymic subpopulations, total thymus, T-ALL, B-cell ALL (B-ALL), and acute myeloid leukemia (AML) primary cells and lines. Mean ± standard deviation are represented. (C-D) Western blot showing AK2 and AK1 expression in T-ALL cell lines (JURKAT, MOLT4, and CEM), B-ALL cell lines (REH and RCH-ACV), and total thymus (Th96 and Th97) (C) andprimary cells from T-ALL samples (UPN#1-UPN#7) (D). The AK2/actin or AK1/actin ratios are represented under each band. (E) AK1 and AK2 transcriptional expression assessed by RNA sequencing in 47 T-ALL primary samples. *P < .05; **P < .01; ***P < .001. 4ISP, CD4-immature single positive; DP, double positive; ns, not significant; SP, simple positive. 

AK2 isoform exhibit robust expression in T-ALL. (A-B) Transcriptional expression of AK2 (A) and AK1 (B) in thymic subpopulations, total thymus, T-ALL, B-cell ALL (B-ALL), and acute myeloid leukemia (AML) primary cells and lines. Mean ± standard deviation are represented. (C-D) Western blot showing AK2 and AK1 expression in T-ALL cell lines (JURKAT, MOLT4, and CEM), B-ALL cell lines (REH and RCH-ACV), and total thymus (Th96 and Th97) (C) andprimary cells from T-ALL samples (UPN#1-UPN#7) (D). The AK2/actin or AK1/actin ratios are represented under each band. (E) AK1 and AK2 transcriptional expression assessed by RNA sequencing in 47 T-ALL primary samples. *P < .05; **P < .01; ***P < .001. 4ISP, CD4-immature single positive; DP, double positive; ns, not significant; SP, simple positive. 

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