ROC curves of angiopoietin-2 and IL-6 courses for in-hospital mortality and nonresolving pulmonary condition in patients with COVID-19. Three-day course for in-hospital mortality of angiopoietin-2 in the (A) derivation and (B) validation cohorts. Three-day course for in-hospital mortality of IL-6 in the (C) derivation and (D) validation cohorts. Ten-day course for nonresolving pulmonary condition of angiopoietin-2 in the (E) derivation and (F) validation cohorts. Ten-day course for nonresolving pulmonary condition of IL-6 in the (G) derivation and (H) validation cohorts.