Correlation analysis of targeted RNASeq data on T-cell blasts from HD controls (n = 5) and patients with DD, HI, or DN mutations. (A) RNASeq was performed using RNA extracted from enriched blasted T cells. Scale bar indicates Pearson correlation coefficient for variance stabilized data for differentially expressed messenger RNA. (B) Venn diagram analysis comparing lists of differentially expressed genes for each IKAROS study group (ie, DD [n = 4], HI (n = 1), DN (n = 1)] vs HD controls (n = 5). (C) Table of differentially expressed genes for the DD study group only as well as differentially expressed genes that are common across groups. Genes overexpressed compared with HD controls are in red text; genes underexpressed compared with HD controls are in blue text. (D) IPA Diseases and Functions Analysis heat map showing a comparison of the predicted effected cellular processes and biological functions based on gene expression. The activation z score represents the bias in gene regulation that predicts whether the biological function exists in an activated (orange) or inactivated (blue) state.