Comprehensive genomic profiling of ALL harboring germline ETV6 variants. (A) Heatmap showing major somatic coding mutations and structural variations identified in cases with a germline ETV6 variant or ETV6-RUNX1 fusion. (B-C) Unsupervised hierarchical clustering of global gene expression profile from cases with germline ETV6 variants (B) or with addition of the 231 pediatric ALL cases of diverse subtypes (C). (D) Somatic genomic features in AML and ALL arising from the same ETV6 germline variant.