Pathological findings of lymph nodes in ATLL with HTLV-1–infected HRS-like cells. (A) Lymph nodes of case 7 were effaced by infiltration of HRS-like cells (inset) in a background of lymphocytes, histiocytes, and eosinophils (hematoxylin and eosin staining). (B-H) The HRS-like cells were positive for CD30 (B), CD15 (C), CD25 (D), HBZ-ISH (E), fascin (F), and CD4 (G) and negative for PAX5 (H). Most of the infiltrating small lymphocytes were T cells positive for CD3 (I) and negative for HBZ-ISH (E). Original magnification ×200 (A) and ×400 (A, inset, and B-I).