Downregulation of IL-6/STAT3 activity in Tcons reestablishes the connectivity of STAT signaling network in Tcons and Tregs. Functional maps of STAT signaling network generated by calculating Spearman’s rank correlation coefficients between pairs of nodes within and among each of Tregs and Tcons before initiation and after 6 cycles of AZA. (A) Although the STAT architecture was completely disorganized in all patients both before and 15 days (D15) after AZA initiation, the AZA-mediated downregulation of IL-6/STAT3 signaling in Tcons was accompanied by restructuring of STAT networks and the formation of numerous positively correlated nodes across Tcons and Tregs on cycle 6 (Cy6). (B) By contrast, the pattern of signaling responses remain disorganized in patients who upregulated IL-6/STAT3 signaling in Tcons after 6 cycles of AZA.