Specific metabolic profile of AML patients according to their prognosis (ELN classification). (A) Score plot of the OPLS-DA model comparing adverse (n = 18) vs favorable (n = 21) prognostic groups (R2Y = 0.751; Q2 = 0.472). (B) Levels of GSH and Asp in favorable group compared with adverse group. Mean value ± SEM. Student t test, *P < .05, **P < .01. (C) The prediction of the patients with intermediate risk in the OPLS-DA model built with adverse and favorable subgroups shows a distribution of the half of these patients in favorable risk (n = 8) and the other half in adverse risk (n = 7).