Changes in metabolites levels according to the immunologic status of patients. (A) Levels of Asp and 2-HG metabolites according to the CD34/MPO status in M0, M1, and M2 subtypes, corresponding to immature AML. (B) Levels of Gln and Pro according to the CD14/CD300e status in M4 and M5 subtypes, corresponding to more mature AML. Mean value ± SEM. Two-way analysis of variance test, ***P < .001.