Specific metabolic profile of AML patients according to the mutational status of NPM1. (A) Score plot of the OPLS-DA model built with HRMAS-NMR data of NPM1 wild-type patients (n = 30) and NPM1-mutated patients (n = 17). The model is robust and predictive (R2Y = 0,726; Q2 = 0,498). We see a clear separation between the 2 groups. (B) Levels of Glu, PC, PCr/Cr, and tau in NPM1 wild-type patients compared with NPM1-mutated patients. Mean value ± standard error of the mean (SEM). Student t test, *P < .05, **P < .01.