Figure 3.
NOTCH2 mutation is associated with higher levels and wider distribution of NICD2 staining in SMZL. (A) Summary of pathogenic single-nucleotide, copy-number, and structural variants identified in 20 cases of SMZL. (B) Summary of NICD2 staining and NOTCH2 mutation status of genotyped SMZL cases. (C) Schematic of NOTCH2 mutations in SMZL. (D) Box-and-whisker plot showing frequency of NICD2+ cells in NOTCH2-mutated and wild-type SMZL (***P < .001). (E) Representative staining for NICD2 in NOTCH2-mutated and wild-type SMZL (original magnification, ×200). (F) Ratio of NICD2+ cells in outer and inner white pulp in NOTCH2-mutated vs wild-type cases (*P < .05). ANK, Ankyrin repeat; EGF, epidermal growth factor; HD, heterodimerization domain; LNR, Lin12/Notch repeat; RAM, RBP-Jκ/CBF1-associated module; TM, transmembrane domain.

NOTCH2 mutation is associated with higher levels and wider distribution of NICD2 staining in SMZL. (A) Summary of pathogenic single-nucleotide, copy-number, and structural variants identified in 20 cases of SMZL. (B) Summary of NICD2 staining and NOTCH2 mutation status of genotyped SMZL cases. (C) Schematic of NOTCH2 mutations in SMZL. (D) Box-and-whisker plot showing frequency of NICD2+ cells in NOTCH2-mutated and wild-type SMZL (***P < .001). (E) Representative staining for NICD2 in NOTCH2-mutated and wild-type SMZL (original magnification, ×200). (F) Ratio of NICD2+ cells in outer and inner white pulp in NOTCH2-mutated vs wild-type cases (*P < .05). ANK, Ankyrin repeat; EGF, epidermal growth factor; HD, heterodimerization domain; LNR, Lin12/Notch repeat; RAM, RBP-Jκ/CBF1-associated module; TM, transmembrane domain.

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