RBC metabolome analysis showed decreased levels of 6 glycolysis intermediates in 10 HX subjects compared with 10 controls. (A) Individual levels of 6 glycolysis intermediates (*P < .05, **P < .01). (B) The decreased metabolites (marked with an asterisk) are shown on as simplified scheme of glycolysis, hexose, and pyruvate levels were not affected. a.u., arbitrary units; CTRL, control.