Change in bleeding time (liver laceration model). (A) Percentage change in bleeding time from baseline when ciraparantag was administered in increasing doses after edoxaban treatment (1 mg/kg) of rats. (B) Scanning electron micrographs of WBCT clots immediately before (T = 0 min) and after (T = 15 and 60 min) IV edoxaban (0.5 mg/kg). Ciraparantag (10 or 20 mg/kg IV) or placebo was administered at the 15-minute time point.