Bobillo et al demonstrated that in stage I DLBCL patients, OS and PFS were shorter in patients with extranodal disease than in patients with nodal involvement. Radiotherapy was associated with longer OS and PFS in patients with extranodal DLBCL. Based on these findings, a depicted treatment algorithm can be proposed. A small number of events did not allow analysis of the value of radiotherapy in patients with nodal presentation and positive PET after chemoimmunotherapy. The figure has been adapted from Figures 3A and 4 in the article by Bobillo et al that begins on page 39.