Benefit in terms of PFS and OS in the validation data. Shown is the better correlation with PFS (A,C,E,G) and OS (B,D,F,H) relative to R-ISS and SKY92 alone. (A-B) Highest-risk R-ISS. (C-D) Highest-risk SKY92. (E-F) Lowest-risk R-ISS. (G-H) Lowest-risk SKY92. For the discovery data, see supplemental Figure 5.