Figure 1.
![Tet2 deletion in hematopoietic cells augments inflammatory phenotype in mouse models of adult HLH. (A) Il-6 transcript levels in Tet2-null (gray) or Tet2–wild-type (black) BMDMs 6 hours after stimulation with ODN1826 (expressed as standard error of the mean [SEM] of 3 replicates). Values were normalized to vehicle control. (B) Cytokine levels in supernatants of Tet2–wild-type (WT) or Tet2-null BMDMs 24 hours after stimulation with vehicle (phosphate-buffered saline) or ODN1826 (ODN), expressed as SEM of 3 replicates. (C) Schematic of the experimental setup. Spleen-to-body weight ratio (D) and hematocrit (Hct) (E) in each group. *P < .05; **P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/136/26/10.1182_blood.2020008206/1/bloodbld2020008206f1.png?Expires=1734585665&Signature=sYUPC9782Z6YYHy3SOSOXS-rvYcUqtDq0kZ1cDkFqeRwipJP3AuZK1TnmAFDdrLMYL~akIOzS6L-t2F9mJypXnB~TiESkDDpkViuPAo1fC1ynNFtjtO~uTJl2EnEKhaA4Lf0qZlMhZEN-2gSrxswjZusdBLo6UYW-uiRE71zq5jyTW9su7NbmRYrzd~W-TjWjZjS7j~CI8ljWfCQuAzZy709QGwNJiKzwYwCqvjr0HABWlNnKxbPeNJeNnQSjknzJZIgEPP05GGIyxNNtod1E8igarNvX~unJrCEOFzprjQJRJ2w-L-mlX20vdP62zEyLaYBjWP9Su1DrEL5HAf-Vg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Tet2 deletion in hematopoietic cells augments inflammatory phenotype in mouse models of adult HLH. (A) Il-6 transcript levels in Tet2-null (gray) or Tet2–wild-type (black) BMDMs 6 hours after stimulation with ODN1826 (expressed as standard error of the mean [SEM] of 3 replicates). Values were normalized to vehicle control. (B) Cytokine levels in supernatants of Tet2–wild-type (WT) or Tet2-null BMDMs 24 hours after stimulation with vehicle (phosphate-buffered saline) or ODN1826 (ODN), expressed as SEM of 3 replicates. (C) Schematic of the experimental setup. Spleen-to-body weight ratio (D) and hematocrit (Hct) (E) in each group. *P < .05; **P < .01.