Impact of NPM1^mut MRD negativity on CIR after 2 induction cycles and at EOT. Patients achieving MRD negativity (MRD^neg, blue curve) had a significantly lower CIR rate compared with patients with MRD positivity (MRD^pos, red curve) after 2 induction cycles (A-B) and at EOT (C-D). This was true for BM (A,C) (after 2 cycles: 4-year CIR rate, 25.3%; 95% CI, 11.2%-39.4% vs 37.9%; 95% CI, 32.1%-43.8%; P = .03; EOT: 4-year CIR rate, 26%; 95% CI, 17.1%-34.9% vs 44.7%; 95% CI, 36.3%-53.1%; P < .0001) and for PB (B,D) (after 2 cycles: 4-year CIR rate, 18.4%; 95% CI, 12.0%-24.9% vs 53.4%; 95% CI, 45.2%-61.6%; P < .0001; EOT: 4-year CIR rate, 28.2%; 95% CI, 20.9%-35.4% vs 70.3%; 95% CI, 57.6%-83.1%; P < .0001). Shaded area represents 95% CI.