Figure 4.
Pathogenic FcγRIIA is provided by the bone marrow. (A) Immunohistochemical staining of FcγRIIA protein (white arrows) in the kidneys of female B/WF1.FcγRIIATGN mice aged 9 and 28 weeks (×400 magnification). Data are representative of n = 5 per group. (B) Left panel: schematic of bone marrow chimera expressing or not FcγRIIA. Right panel: survival analysis of bone marrow chimera expressing or not FcγRIIA on bone marrow cells (n = 5 per group). (C) Kidney immunofluorescence staining in bone marrow chimera with SLE. Nuclei are stained with 4′,6-diamidino-2-phenylindole (DAPI) (blue), and white arrows indicate FcγRIIA+ cells (orange). Single staining is presented in supplemental Figure 5. Scale bar, 50 µm. (B) Statistical analyses, log-rank survival analysis. *P < .05, **P < .01.

Pathogenic FcγRIIA is provided by the bone marrow. (A) Immunohistochemical staining of FcγRIIA protein (white arrows) in the kidneys of female B/WF1.FcγRIIATGN mice aged 9 and 28 weeks (×400 magnification). Data are representative of n = 5 per group. (B) Left panel: schematic of bone marrow chimera expressing or not FcγRIIA. Right panel: survival analysis of bone marrow chimera expressing or not FcγRIIA on bone marrow cells (n = 5 per group). (C) Kidney immunofluorescence staining in bone marrow chimera with SLE. Nuclei are stained with 4′,6-diamidino-2-phenylindole (DAPI) (blue), and white arrows indicate FcγRIIA+ cells (orange). Single staining is presented in supplemental Figure 5. Scale bar, 50 µm. (B) Statistical analyses, log-rank survival analysis. *P < .05, **P < .01.

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