Cytogenetics and fusion proteins in pediatric AEL versus other pediatric AMLs. Compared with all other centrally reviewed AMLs, AEL had fewer cytogenetic abnormalities of inv(16)/t(16;16), t(8;21), monosomy 7, and 11q23 abnormalities (the last being statistically significant). However, AEL was enriched in NUP98 fusions compared with the other subtypes of AML (analyzed from the AAML1031 cohort).