CircRNA expression is deregulated in T-ALL. (A) Expression heatmap of the 103 circRNAs most deregulated in T-ALL compared with thymocytes from healthy donors (DESeq adjusted P < .01, log fold change [LFC] > 1, and mean expression >5; names are shown for the circRNAs with mean expression >10). (B) Scatterplot of significant absolute expression and CLP variation (LFC) comparing T-ALL with thymocytes; the marginal distributions of LFC(CLP) and LFC(Expression) values are shown, indicating the mean values; red and green dots indicate concordantly positive or negative LFC of expression and CLP, and dark yellow dots indicate discordant variations; names are shown for circRNAs with LFC(CLP) > LFC(Expression) and absolute expression of at least 10. Expr., expression.