Clinical and genetic features of patients harboring mutations in CD27 and CD70. (A) Identified variants in CD27 (top) and CD70 (bottom). Corresponding publications for previously reported mutations are indicated in brackets. (B) Comparison of clinical findings and outcomes in CD27- and CD70-deficient patients. (C) Clinical manifestations of CD27 and CD70 deficiencies. IBD, inflammatory bowel disease; RTI, respiratory tract infection.