American Society of Hematology

Figure 1.

Dosing schedule by arm and time on study. Arm A (chemotherapy-free): VEN (800 mg daily) + R (375 mg/m2). Arm B (chemotherapy containing): VEN (800 mg daily) + B (90 mg/m2) + R (375 mg/m2). Arm C (chemotherapy containing): B (90 mg/m2) + R (375 mg/m2). *R administered on days 1, 8, 15, and 22. Safety run-in arm (not displayed above) consisted of 9 patients that received VEN (600 mg daily for 1 year) + B (90 mg/m2 on days 1 and 2 of each 28-day cycle) + R (375 mg/m2 on day 1 of each cycle). D, day.

Dosing schedule by arm and time on study. Arm A (chemotherapy-free): VEN (800 mg daily) + R (375 mg/m²). Arm B (chemotherapy containing): VEN (800 mg daily) + B (90 mg/m²) + R (375 mg/m²). Arm C (chemotherapy containing): B (90 mg/m²) + R (375 mg/m²). *R administered on days 1, 8, 15, and 22. Safety run-in arm (not displayed above) consisted of 9 patients that received VEN (600 mg daily for 1 year) + B (90 mg/m² on days 1 and 2 of each 28-day cycle) + R (375 mg/m² on day 1 of each cycle). D, day.

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