Summary of FVIII-binding antibodies for all patients in subgroups 2 and 4. (A-B) Medians and IQRs for titers and apparent affinity constants of FVIII-binding antibodies, differentiated for IgG subclasses 1-4, IgM and IgA, as detected in patients in subgroup 2, who did not develop FVIII inhibitors (A), and patients in subgroup 4, who developed persistent FVIII inhibitors (B). The calculation of medians and IQRs for titers and apparent affinity constants included all antibody data for each patient in the respective subgroup at each time point analyzed.