GDNF/GFRα1 induces an array of downstream responses upon associating with the RET receptor in cultured cord blood HSCs. Illustrated pathways were identified through a combination of kinome profiling, mass cytometry, and assessment of RNA level changes. Activating (green) and inhibiting (red) phosphorylations, protein levels or RNA levels, and proposed modes of action are shown. Altogether, RET stimulation promotes a coordinated program of increased HSC proliferation, survival, and resistance to oxidative stress to potentiate HSC expansion. See Figure 5E in the article by Grey et al that begins on page 2535.