Mutational landscape of 54 t(14;18)⁻FLs. Bar graphs (left) show the 20 genes analyzed, and the results are given in number of mutated (blue) and nonmutated (red) cases. A diagram of the relative positions of driver mutations (right) is shown for STAT6, CREBBP, and TNFRSF14. The x-axis indicates the amino acid positions. The approximate location of somatic mutations identified in each gene is indicated. STAT6 mutations are mainly in the DNA binding domain with 3 hot spots. Mutations in CREBBP are mainly identified in the HAT-KAT domain and a hot spot in p.S1680del. Mutations in TNFRSF14 are identified mainly in the 3 first exons. The protein with its different domains (bottom) and the cysteine repeats TNFR-Cys 1-3. Domains of the protein are represented according to the Uniprot database (www.uniprot.org).