Validated morphologic profiles and genetic signatures. (A) Venn diagram depicts associations identified by LR patients for discovery and validation groups, respectively. After evaluating the significant pairs of morphologic profiles and genetic signatures in the discovery cohort for LR compared with those in the validation cohort for LR, 6 pairs (black box) were recapitulated in both. (B) Diagram depicting 6 validated morphologic and genetic associations. (C) Resultant validated associations between morphologic profiles and genetic signatures.