Genetic signatures in HR MDS. (A) Consensus clustering applied to genetic mutations identify a signature with 6 subtypes (HR-SA through HR-SF) among HR patients in the discovery cohort. (B) Distribution of mutations within each genetic signature. Frequently mutate genes (in ≥5% of patients) are shown. (C) Kaplan-Meier curves compare overall survival among patients identified by 6 genetic subtypes; the P value is from the log-rank test. (D) Distribution of morphologic profiles in each genetic signature. Frequent profiles (in >15% of patients) in each genetic signature are depicted. (E) The presence of specific morphologic features across morphologic profiles and genetic signatures. Representative morphologic features are shown in rows; frequent pairs of morphologic profiles and genetic signature are displayed as columns.