Increased HSC resistance to oxidative stress in diabetic mouse models. (A-F) In vitro activity of HSC-SLAMs tested in methylcellulose assay after 30 minutes of in vitro treatment with medium or ROS (H₂O₂: 100 µM). (A) Experimental scheme. (B) Relative clonogenic activity of HSC-SLAMs isolated from db (B), MS-NASH (C), Ins2^Akita (D), ob (E), and Apoe^−/− (F) mouse models compared with their respective controls. Graph indicates the relative percentage ± standard deviation of colony number in each condition (n = 3 performed in triplicate). Two-way ANOVA with Sidak’s post hoc test; **P ≤ .0001; ****P ≤ .0001.