A new ILK-dependent pathway of LFA-1 activation on neutrophils. ILK facilitates recruitment of PCK-α to the cell membrane where it supports phosphorylation of a specific residue in kindlin-3. This modification enhances the capacity of kindlin-3 to cooperate with talin-1 to activate integrin LFA-1 and its recognition of ICAM-1. Illustration by Katarzyna Bialkowska.