Thrombin generation and plasma clot properties in patients with blood group O vs non-O
| . | Blood group O (n = 169) . | Blood group non-O (n = 195) . | P . | BHC . | P* . | BHC* . |
|---|---|---|---|---|---|---|
| Thrombin generation | ||||||
| Lag time, mean (SD), min | 11.2 (3.0) | 11.0 (2.8) | .606 | NS | .870 | NS |
| Velocity index, median (IQR), nmol/L per min | 30.6 (18.3-51.8) | 34.8 (18.0-59.8) | .272 | NS | .102 | NS |
| Peak thrombin, mean (SD), nmol/L | 244.4 (113.4) | 258.8 (125.2) | .254 | NS | .086 | NS |
| TTP, median (IQR), min | 18.1 (15.6-21.6) | 17.6 (14.6-21.6) | .174 | NS | .347 | NS |
| AUC, mean (SD), nmol/L × min | 3234.2 (737.5) | 3287.0 (702.7) | .485 | NS | .320 | NS |
| Plasma clot properties | ||||||
| Lag time, median (IQR), min | 11.1 (8.2-14.4) | 9.5 (6.9-13.6) | .028 | NS | .145 | NS |
| Vmax, mean (SD), OD/min | 0.13 (0.05) | 0.14 (0.05) | .078 | NS | .575 | NS |
| ΔAbs, OD 405 nm, mean (SD) | 0.74 (0.17) | 0.74 (0.17) | .792 | NS | .004 | <.05 |
| TTP, mean (SD), min | 20.5 (7.1) | 18.7 (6.4) | .009 | <.05 | .069 | NS |
| CLT, median (IQR), min | 16.0 (13.5-19.7) | 16.3 (13.5-19.7) | .989 | NS | .145 | NS |
| . | Blood group O (n = 169) . | Blood group non-O (n = 195) . | P . | BHC . | P* . | BHC* . |
|---|---|---|---|---|---|---|
| Thrombin generation | ||||||
| Lag time, mean (SD), min | 11.2 (3.0) | 11.0 (2.8) | .606 | NS | .870 | NS |
| Velocity index, median (IQR), nmol/L per min | 30.6 (18.3-51.8) | 34.8 (18.0-59.8) | .272 | NS | .102 | NS |
| Peak thrombin, mean (SD), nmol/L | 244.4 (113.4) | 258.8 (125.2) | .254 | NS | .086 | NS |
| TTP, median (IQR), min | 18.1 (15.6-21.6) | 17.6 (14.6-21.6) | .174 | NS | .347 | NS |
| AUC, mean (SD), nmol/L × min | 3234.2 (737.5) | 3287.0 (702.7) | .485 | NS | .320 | NS |
| Plasma clot properties | ||||||
| Lag time, median (IQR), min | 11.1 (8.2-14.4) | 9.5 (6.9-13.6) | .028 | NS | .145 | NS |
| Vmax, mean (SD), OD/min | 0.13 (0.05) | 0.14 (0.05) | .078 | NS | .575 | NS |
| ΔAbs, OD 405 nm, mean (SD) | 0.74 (0.17) | 0.74 (0.17) | .792 | NS | .004 | <.05 |
| TTP, mean (SD), min | 20.5 (7.1) | 18.7 (6.4) | .009 | <.05 | .069 | NS |
| CLT, median (IQR), min | 16.0 (13.5-19.7) | 16.3 (13.5-19.7) | .989 | NS | .145 | NS |
AUC, area under the curve; CLT, clot lysis time; OD, optical density; TTP, time to peak.
ANCOVA, adjusted for sex and VWF:Ag, VWF:RCo, and FVIII levels.